SYNOLIS VA

VISCO-ANTALGIC

EFFECT FOR
SWIFT RELIEF

Synolis VA is a proprietary, highly stable, dense, smart gel formulation.

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Synolis VA

Synolis VA combines hyaluronic acid 2% and sorbitol 4%. These two components work synergistically to deliver a high-performance gel formulation.

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HYALURONIC ACID 2%:

- High lubrication
- Better shock absorbance

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SORBITOL 4%:

- Strong endogenous antioxidant
- Protection of hyaluronic acid

SYNOLIS VA RHEOLOGICAL PROPERTIES

Synolis VA has enhanced rheological properties that are inspired by young and healthy synovial fluid.

Synolis VA is designed to reach the optimal crossover frequency (0.4 Hz), at which the switch from viscosity to elasticity occurs. Outperforming the viscoelastic properties of the young and healthy synovial fluid, Synolis VA responds to the needs of osteoarthritis (OA) joints in an optimal way. 1

Synolis VA is 21% more viscous and 54% more elastic compared to young and healthy joint fluid at 2.5Hz 2
The improved rheological properties of the synovial fluid after the injection of Synolis VA provide osteoarthritis patients with many benefits 1
- Reduced bone contact
- Raised cartilage protection
- Improved shock absorbance
- Restoration of joint function

SYNOLIS VA IS A SORBITOL-POWERED COMBINATION
Sorbitol is also key to the structural integrity of Synolis VA. It has a high affinity for HA and helps stabilize the structure of Synolis VA via a dense network of hydrogen bonds. Synolis VA contains a high concentration of sorbitol (40 mg/ml).1,2
The high concentration of sorbitol has a stronger protective effect on HA than crosslinked products 5,6

SYNOLIS VA POSITIVELY IMPACTS CARTILAGE QUALITY
Osteoarthritis (OA) negatively impacts the quality of the cartilage, causing it to become thinner which can lead to intense pain. 3
Synolis VA has been demonstrated to improve cartilage quality. In a study assessing the effect of Synolis VA on cartilage quality across 3 parameters (‘modulus’, ‘indentation force’ and ‘indentation depth’), cartilage elasticity increased after overnight incubation in Synolis VA. 4,5

Osteoarthritis patient feeling good and running
Physician

SYNOLIS VA BENEFITS

Choose Synolis VA for your osteoarthritis patients.

  • Non-animal sources hyaluronic acid 9
  • Patented viscoelastic properties 1
  • Breaks the oxidative loops 10,11
  • Improves cartilage elasticity 12
  • Unique Visco-Antalgic effect 7,8
  • Single Session treatment 13,3

Patient’s benefits:

- Improvement of the mobility
- Less co-medication
- Better quality of life

Physician’s expectations:

- Improvement of the joint function
- Reduction of the inflammation
- Improvement of cartilage quality

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SYNOLIS VA RANGE

Flexibility of treatment for fast and
long-lasting pain relief.

CLINICAL EFFICACY

Synolis VA has a powerful visco-antalgic effect for swift relief.

A multicentre, non-interventional study including 1,147 patients with radiologically confirmed Osteoarthritis of any joint (93% knee joint) was carried out to examine the efficacy and tolerability of Synolis VA in routine clinical practice. 7,8

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Scientist
Synolis VA gel with logo

TREATMENT RESPONSE

Synolis VA delivers fast and intense relief from pain. 7

Patients subjectively assessed pain and functional impairement due to Osteoarthritis using a 5-point Likert scale, before treatment with Synolis VA, and at regular intervals during the following 24 weeks.

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The Truth: You should be physically active when you have arthritis. Not only will appropriate activities decrease your osteoarthritis pain, they can improve range of motion, function, and reduce disability.

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