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MOBILITY
INJECTION
FOR LONG-LASTING PAIN RELIEF
WHAT IS SYNOLIS VA?
Hyaluronic Acid 2% + Sorbitol 4%
- A solution injected in osteoarthritis joints
- A unique combination of hyaluronic acid and sorbitol
- An innovative and patented solution
- A product provided by Aptissen
- Formulation: Hyaluronic Acid 2% + Sorbitol 4%
- A smart gel injected into joints
- Unique combination of hyaluronic acid and sorbitol that works like a natural lubricant for osteoarthritis joints*
- 4 ml syringe of Synolis VA contains 80 mg of Hyaluronic Acid (HA) and 160 mg of sorbitol
- Patented visco-elastic properties: Synolis VA is the only viscoadaptative gel with the same crossover frequency as young and healthy synovial fluid
- An innovative solution: Synolis VA maintains cartilage integrity in vitro and relieves osteoarthritic patients from pain 1
- A product provided by Aptissen, a Swiss company that has been committed to helping patients for the past 25 years
Note:
*Sorbitol is an antioxidant that is found in apples and pears. It is used in a variety of everyday products, such as foods, cosmetic creams, toothpaste, and medications. Sorbitol helps preserve the Hyaluronic Acid.
SYNOLIS VA
BENEFICIAL EFFECTS
In healthy joints, a natural lubricant known as synovial fluid helps reduce friction between cartilage – a rubber-like padding at the ends of bones. 6-8
The body’s natural Hyaluronic Acid is a key part of synovial fluid. Hyaluronic Acid has unique features that enable synovial fluid to adapt its viscosity based on what you’re doing. For example, if you’re sitting down, the synovial fluid will have a thick consistency to help reduce friction between the cartilage. While you are walking, synovial fluid will become more elastic, helping to absorb the shock from each step. Therefore, the synovial fluid is said to be viscoadaptive. 7-9
In osteoarthritic joints, levels of Hyaluronic Acid are reduced. This means that synovial fluid can no longer adapt its viscosity as well as before. As a result, friction between cartilage increases, wearing it down and causing bones to grind against each other during movement. This leads to symptoms such as pain, swelling, stiffness and reduced joint function. 10-12
When injected into the joint, Synolis VA works by mimicking synovial fluid. Synolis VA is viscoadaptive and adapts to your movements in the same way that synovial fluid does. Friction between the cartilage is therefore kept to a minimum, helping the joint function normally again and providing fast, long-lasting pain relief. 2,3,4,9
FLEXIBLE TREATMENT WITH SYNOLIS VA
Patients’ well-being is central to our concerns.
Because all patients are different, we have developed the Synolis VA range, which can be used as a single or multi-injection to relieve patients from pain and improve their mobility.
Synolis VA 40/80 – 2 ml: 40 mg of Hyaluronic Acid and 80 mg of Sorbitol
Mono or multi injection for knee osteoarthritis
Synolis VA 80/160 – 4 ml: 80 mg of Hyaluronic Acid and 160 mg of Sorbitol
Mono injection for knee osteoarthritis
What I need to remember?
Synolis VA is long lasting.
It relieves pain for at least 6 months.
SHOULD I GET A TREATMENT WITH HYALURONIC ACID?
Hyaluronic acid (HA), a component of synovial fluid, is the thick fluid that acts as a lubricant in joints.
Intra-articular injection of Hyaluronic Acid, or viscosupplementation, consists of an injection of exogenous Hyaluronic Acid into the joint.
Furthermore, in knee osteoarthritis, modifications of Hyaluronic Acid in synovial fluid and the deterioration of cartilage lead to the release of damaging biological products that cause inflammation. The injected Hyaluronic Acid replenishes the synovial fluid and replaces modified Hyaluronic Acid, helping to lubricate the joint and ease symptoms. Hyaluronic Acid injections can provide pain reduction in mild osteoarthritis of the knee for up to 24 weeks. 22
The use of intra-articular Hyaluronic Acid therapy to treat osteoarthritis is growing worldwide, due to important results obtained from several clinical trials, which reported intra-articular Hyaluronic Acid - related improvements in functional activity and pain management. 23,24
ILÁ NORTHFLEET TREATED WITH
SYNOLIS VA 80/160
“After the first injection of the Synolis VA I returned to the tennis matches as if I had new legs!”
- Age: 75 years old
- From: Brazil
- Single Dose Treatment
- Right knee: One syringe of SYNOLIS VA 80/160
- Left knee: One syringe of SYNOLIS VA 80/160
1- How old are you? Your Hobbies?
I am 75 years old, I like to paint watercolors, to bike on the beach, to take care of the garden, to play tennis, to do aqua aerobics and to cook for my family.
2- When was your problem diagnosed? What was the degree of injury?
It’s been about 3 years since I’ve had diffuse pain in my legs in general, not just my knees. I could not define the degree of the injury. In the consultation with the orthopaedist and with radiological examinations it was found that both knees were compromised by the lack of cartilage.
3- How did osteoarthritis change your life? What did you like to do, for example, and did you have to stop doing?
The movement limitation caused by osteoarthritis appeared in the game of tennis and in prolonged walks. I had to decrease my activity on the tennis court and I became less competitive, I often called for analgesics or anti-inflammatories after the game.
4- After receiving the treatment from SYNOLIS VA, did you feel able to resume your activities? Have you ever felt that treatment with SYNOLIS VA has given you back your “normal” life?
After the first injection of the Synolis VA I returned to the tennis matches as if I had new legs!
5- After the injection, how long have you felt the first symptom of pain relief? And in relation to the movement, was there amplitude, improvement?
It was almost immediate. I had pain when going downstairs and on the same day of the injection I needed to go down a stair and I no longer felt pain in the legs! From then and on, I played tennis twice a week for an hour and a half.
6- How long did SYNOLIS VA result in you? Regarding pain? What about the mechanics of movement?
I only went to the doctor to make a new injection a year later. I only feel pain when I push myself hardly and after my abusive efforts. I am still learning to deal with the limitations I have, due to my age.
7- Was there any disadvantage?
I found no disadvantage. It was an easy and painless procedure and with long-lasting effect.
8- Would you like to share some experience?
I have been speaking about the benefits of this treatment to my hydrogymnastics mates who have problems with osteoarthritis.
9- Did you try any other type of treatment? If so, what were the results?
I did nothing other than the use of Synolis VA.
10- Would you recommend SYNOLIS VA?
Yes, with no restrictions!
VISITING YOUR DOCTOR
If you are experiencing symptoms such as joint pain, stiffness and swelling, talk to your doctor about whether you have osteoarthritis.
Before your visit it would be a good idea to write a list that includes: 14
- Your symptoms and when you experience them e.g. “my knee is very stiff when I wake up I the morning”
- Details of any other medical problems you have
- Details of any other medical problems in your family
- All the prescription and over-the-counter medications and dietary supplements you take, when and in what dose
- Questions you want to ask the doctor
During your appointment your doctor may do the following:
Ask questions:
Your doctor will most likely ask when the joint problems began and whether the symptoms come and go or if that are constant. He or she will want to know if any particular activities make them worse, such as climbing the stairs or writing with a pen. It will also be important for them to know if the affected joint has been injured in the past. 14
Carry out a physical examination:
During the physical examination your doctor will look for a number of things such as tenderness, swelling or redness, creaking and swelling, and for the range of motion in the joint. 15,16
Perform tests:
Your doctor may order imaging tests such as x-rays or magnetic resonance imaging (MRI) to obtain pictures of the affected joint. They may also order blood or joint fluid tests. Certain blood tests may help rule out other causes of joint pain, such as rheumatoid arthritis. Joint fluid can also be tested to see if there's inflammation and if your pain is caused by gout or an infection. Osteoarthritis can vary in intensity, ranging from mild to moderate to severe. 15,16
Discuss treatments:
There are several different treatment options that depend on which joint is affected, the symptoms and their severity. Your doctor will talk with you to work out a plan that is right for you. 17
What I need to remember?
If you are experiencing symptoms such as joint pain, stiffness and swelling,
talk to your doctor about whether you have osteoarthritis.
OTHER TREATMENT OPTIONS
Your doctor will talk to you about finding a plan that suits your needs. Doctors usually treat osteoarthritis with a combination of therapies:18
- Lifestyle modifications
- Exercise
- Weight Management
- Orthotic devices
- Medications
- Topical (placed directly on the skin)
- Oral (by mouth)
- Injections (shots)
- Dietary supplements
- Surgery
Lifestyle modifications:
There are several ways of relieving osteoarthritis symptoms without using medications. 19-20
Exercise:
Although it might seem counterintuitive, physical activity can help osteoarthritis. Not only will appropriate activities decrease osteoarthritis pain, they can improve motion and function. Your doctor may recommend activities such as walking, swimming, water aerobics. Find out more here.
Weight management:
A weight loss program may be recommended, if needed, particularly if osteoarthritis affects weight-bearing joints (such as the knee, hip, spine, or ankle). Excess weight puts stress on your joints so removing that stress can relieve symptoms.
Orthotic devices:
These support (“assistive”) devices, such as a knee brace or shoe insert, can help by taking strain off joints.
Medications:
There are different types of medication that may help osteoarthritis: 20,21
Topical (placed directly on the skin):
Topical pain relievers can be applied directly on the skin over the affected joints. These medicines include capsaicin cream, lidocaine and diclofenac gel.
Oral (by mouth):
Oral pain relievers such as paracetemol are common first treatments. So are nonsteroidal anti-inflammatory drugs (often called NSAIDs), which decrease swelling and pain.
Injections (shots):
Joint injections with hyaluronic acid can also give months of pain relief from osteoarthritis. Find out more here.
Dietary supplements:
Many over-the-counter nutrition supplements have been used for osteoarthritis treatment. Most lack good research data to support their effectiveness and safety. Consult your doctor or pharmacist before using any of these supplements. This is especially true when you are combining these supplements with prescribed drugs.
Surgery:
Surgical treatment is an option for severe osteoarthritis, however not everyone can have surgery: 20
Surgical intervention can be considered when the joint has serious damage, or when medical treatment fails to relieve pain and there is major loss of function. Surgical options for osteoarthritis include joint replacement.
What I need to remember?
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True of false?
You can’t or shouldn’t exercise once you’ve got osteoarthritis.
Choose an answer
The Truth: You should be physically active when you have arthritis. Not only will appropriate activities decrease your osteoarthritis pain, they can improve range of motion, function, and reduce disability.
Did you know ?
What is the percentage of people affected by osteoarthritis over 65 years old?
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Did you know ?
What is the percentage of people affected by osteoarthritis over 65 years old?
Choose an answer